Research Paper Volume 5, Issue 7 pp 551—574

Figure 9. LCA alters the age-related chronology of four longevity-defining cellular processes confined to and regulated by mitochondria. Cells were cultured in the nutrient-rich YP medium initially containing 0.2% glucose with 50 μM LCA or without it, in the presence of 1% DMSO (A - D) or in its absence (E - H). The dynamics of age-related changes in the rate of oxygen consumption by cells (A, E), electrochemical potential across the IMM (B, F), intracellular concentration of ROS (C, G) and cellular level of ATP (D, H) during chronological aging of yeast. Data are presented as means ± SEM (n = 3−7).