Research Paper Volume 5, Issue 7 pp 539—550
Rapamycin doses sufficient to extend lifespan do not compromise muscle mitochondrial content or endurance
Figure 4. Rapamycin does not affect treadmill endurance. 8 week old male C57BL/6 mice were injected with rapamycin (2mg/kg/day) for 2 weeks, then subjected to exercise capacity test. (A) Exercise protocol - mice were placed on treadmill and given a 10-minute warm up period, followed by increases in speed at 12-minute intervals. (B) Total running distance. Error bars show s.e.m; n=9. (C, D) Cumulative shocks for individual (C) or pooled (D) control and rapamycin treated mice.