IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

Jorge Azpurua; Jiang-Nan Yang; Michael Van Meter; Zhengshan Liu; Julie Kim; Aliny AB Lobo Ladd; Antonio Augusto Coppi; Vera Gorbunova; Andrei Seluanov

doi:doi:10.18632/aging.100552

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Research Paper Volume 5, Issue 4 pp 304—314

IGF1R levels in the brain negatively correlate with longevity in 16 rodent species

Figure 3. Levels of IGF1R protein in lung tissue do not correlate with lifespan or body mass. (A) Western blots showing IGF1R and actin bands. (B) Log-transformed graph of IGF1R intensity plotted against maximum lifespan shows very weak (non-significant) correlation (r²=0.05). (C) Log-transformed graph of IGF1R intensity plotted against average adult body mass show very weak (non-significant) correlation (r²=0.18, p=0.11). Error bars are s.d.