Figure 2. Low mTOR/S6K activity: insulin sensitivity plus longevity. (A) Calorie restriction. Deactivation of the nutrient-sensing mTOR pathway results in insulin sensitivity.
(B) Knockout of S6K1 in mice abolishes feedback block of insulin signaling, resulting in insulin sensitivity [
(C) Decreased levels of growth hormone (GH). In mice, absence of GH or GH receptor leads to a remarkable extension of longevity [
(D) Acute treatment with rapamycin. Deactivation of the nutrient-sensing mTOR pathway abolishes a feedback block of insulin signaling, resulting in insulin sensitivity [