Research Paper Volume 4, Issue 4 pp 279—289

Figure 2. Rapamycin inhibits testis growth and reduces body weight. (A) Testes from mice chronically treated with rapamycin for 2 weeks (days 12 through 25) were significantly smaller in size. Representative images of a rapamycin-exposed testis (right) and a control vehicle-exposed testis (left). (B) Rapamycin-exposed mouse testes exhibited significantly diminished weights (12.60 ± 0.492 mg vs 33.52 ± 0.968 mg average testis weight; N=10, ***p<0.001). (C) Body weights of rapamycin-exposed mice were significantly reduced (8.783 ± 0.155 g vs 13.35 ± 0.345 g average body weight; N=5, ***p<0.001). (D) When controlled for body weight, rapamycin-exposed testes exhibited significantly lower values (1.44 mg/g body weight vs. 2.52 mg/g body weight; N=5, ***p<0.001).