Research Paper Volume 4, Issue 2 pp 133—143
Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting
Figure 4. Expression of MEF2C and gene targets governing muscle structural integrity and energy homeostasis. Expression of MEF2C at (A) gene (n = 4) and (B) protein levels (n = 3). Expression of MEF2C target genes which govern (C) muscle structural intergrity and (D) energy homeostasis. Data are presented as arithmetic means ± SEM. *p < 0.05, ***p < 0.001 compared to non-tumor-bearing (non-TB) controls (n = 4). Expression of MEF2C was downregulated at both mRNA and protein levels. Altered mRNA expression was also seen in myozenins (myoz), myokinase (Mk) and myoglobin (Mb) which indicated disrupted muscle structure integrity and energy homeostasis in skeletal muscle during cancer cachexia.