Research Paper Volume 4, Issue 2 pp 133—143
Disruption of MEF2C signaling and loss of sarcomeric and mitochondrial integrity in cancer-induced skeletal muscle wasting
Figure 2. mRNA expression of signaling molecules of the IL-6 signal transduction cascade. (A) Gene expression of Socs3, Il6ra, gp130, Tnfr1 and Tnfr2 were assessed as an indicator of inflammatory signaling (n = 4). Expression of all genes was increased at the endpoint in C26-bearing mice. (B) Longitudinal experiments demonstrated the rise of plasma IL-6 preceded the significant increase of Socs3 and Il-6ra at the transcript level. Data are presented as arithmetic means ± SEM. *p < 0.05, **p < 0.01, ***p < 0.001 compared to non-TB controls (n = 4 expect the non-TB groups on day 8 (n = 3) and day 14 (n = 2)).