Research Paper Volume 3, Issue 10 pp 1018—1027

Figure 3. Age-associated DNA-methylation changes at five CpG sites in the training-group. Methylation level of five selected CpG sites plotted against donor age. Regression coefficients and equations of linear regression are provided (A). Beta-values of the training group samples were used for the linear regression models to predict the donor age (R²= 0.65) (B). Alternatively, the signature was narrowed down to three CpG sites (R²= 0.56) (C).