Research Paper Volume 3, Issue 6 pp 621—634
Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle
Figure 3. Extracellular Ni2+ reduces tetanic force in young skeletal muscle. (A) An intact EDL muscle was electrically stimulated at 37°C with low frequency and high-frequency in a bath solution with 2.5 mM [Ca]o (control) and following addition of 1 mM NiCl2. Ni inhibits force generated with high- but not low-frequency stimulation. (B) An intact SOL muscle was electrically stimulated at 37°C with high-frequency in a bath solution with 2.5 mM [Ca]o (control) and following addition of 1mM and 5mM NiCl2. A cumulative effect to NiCl2 is noted. (C) Data summary for the effects of NiCl2 on EDL muscle at T = 37° C (n = 8, p < 0.01). (D) Data summary for the effects of NiCl2 on SOL at T = 37° C (n = 6, p < 0.01).