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Research Paper Volume 3, Issue 6 pp 621—634

Store-Operated Ca2+ Entry (SOCE) Contributes to Normal Skeletal Muscle Contractility in young but not in aged skeletal muscle

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Figure 2. Removal of [Ca2+]o reduces tetanic contractile force in young skeletal muscle. (A) An Intact EDL muscle was electrically stimulated with low and high frequency in a bath solution with either 2.5 mM [Ca]o (control) or 0 [Ca]o+0.1 mM EGTA. (B) An Intact SOL muscle was electrically stimulated with high frequency in a bath solution with either 2.5 mM [Ca]o (control) or 0 [Ca]o+0.1 mM EGTA. Fast recovery upon return of preparations to 2.5 mM [Ca]o is observed. (C) Data summary for the effects of 0 [Ca]o on EDL muscle at T = 25° C (n = 12, p < 0.01). (D) Data summary for the effects of 0 [Ca]o on SOL muscle at T = 25° C (n = 10, p < 0.01).