Figure 7 — The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

Research Paper|Volume 3, Issue 3|pp. 277–290

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

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Figure 7.Induction of senescence by loss of Wrn helicase activity in Safb1-null MEFs. (A) Example of senescence-associated β-galactosidase staining in Safb1-null and Safb1-null/Wrn^Δhel/Δhel MEFs. Arrowheads point to positive cells. Magnification 100X. (B) Percentage of cells stained with senescence-associated β-galactosidase in wild type, Wrn^Δhel/Δhel, Safb1-null, and Safb1-null/Wrn^Δhel/Δhel MEFs. (Unpaired student t-test; *P < 0.045 and ** P < 0.022 compared to wild type MEFs). Bars represent SEM.