Research Paper Volume 2, Issue 12 pp 981—989
CD36 plays an important role in the clearance of oxLDL and associated age-dependent sub-retinal deposits
Figure 1. CD36 deficiency inhibits oxLDL uptake by RPE cells and leads to oxLDL accumulation. (A) oxLDL concentrations in plasma increase with normal aging. Immuno-localization of oxLDL (green) on frozen sections of retina from 12 months (mo)-old CD36+/+ (B) and CD36−/−. (C) mice. In vivo incorporation of fluorescent DiI-tagged oxLDL (red) by retinal pigment epithelium (RPE) administered intravenously in 2-month-old CD36+/+ (D) and CD36−/− mice (E). In vitro uptake of DiI-oxLDL by RPE from CD36+/+ mice (F) or CD36−/− mice (G). Cells and sections were counterstained with Dapi (blue). Ch Choriocapillaris. Scale bar: 10μm. Values are mean ± SEM; n=4-6/group. * p<0.05 compared to values without asterisks.