Research Perspective Volume 2, Issue 10 pp 731—734

Insights into Cdc13 dependent telomere length regulation

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Figure 1. Model of Cdc13 dependent telomere length regulation. (A) Primary structure of Cdc13 showing the distinct domains in color. (B) CST dependent telomere capping during late S to G2 phase. The DBD and Cdc13N domains of Cdc13 are shown in yellow and blue color respectively. Stn1 and Ten1 are shown in lemon and red color respectively. (C) Telomerase (green claw) recruitment to the telomeres by Cdc13. The telomerase proteins Est1 and Est3 are shown in purple and cyan color respectively. (D) Telomerase loading and pol α (green oval) recruitment to the telomeres.