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Research Paper Volume 2, Issue 10 pp 691—708

Regulatory roles of tankyrase 1 at telomeres and in DNA repair: suppression of T-SCE and stabilization of DNA-PKcs

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Figure 2. Increased γ-ray mutagenicity in WTK1 lymphoblasts upon tankyrase 1 siRNA depletion and/or inhibition of PARP with 3-AB. Cells were treated (representative knockdown, Figure S3), then irradiated the next day. Data are the average of three independent determinations; error bars are standard deviations. (M) mock transfection, (T) tankyrase 1 siRNA, (3-AB) inhibitor, and (T/3-AB) two combined.