Research Paper Volume 2, Issue 11 pp 775—784

Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

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Figure 6. The effects of nesfatin-1 on plasma ACTH and corticosterone concentrations. Plasma ACTH levels at 10 min (A) and corticosterone levels at 15 min (B) after icv administration of nesfatin-1 (0.5 nmol/5 μl) were increased compared with saline administration. *p < 0.05 vs. saline.