Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Natsu Yoshida; Yuko Maejima; Udval Sedbazar; Akihiko Ando; Hideharu Kurita; Boldbaatar Damdindorj; Eisuke Takano; Darambazar Gantulga; Yusaku Iwasaki; Tomoyuki Kurashina; Tatsushi Onaka; Katsuya Dezaki; Masanori Nakata; Masatomo Mori; Toshihiko Yada

doi:doi:10.18632/aging.100207

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Research Paper Volume 2, Issue 11 pp 775—784

Stressor-responsive central nesfatin-1 activates corticotropin-releasing hormone, noradrenaline and serotonin neurons and evokes hypothalamic-pituitary-adrenal axis

Figure 5. The effect of nesfatin-1 on [Ca²⁺]_i in CRH neurons in the PVN. Administration of 10^-10 M nesfatin-1 increased [Ca²⁺]_i in a single neuron isolated from PVN (left panel) that was subsequently shown to be IR to CRH (light panel). The bar above the tracing indicates the period of nesfatin-1 administration. Four out of 16 (25%) neurons that responded to nesfatin-1 were CRH-IR neurons.