Research Paper Volume 2, Issue 10 pp 659—668
Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes
Figure 4. Trichostatin A (TSA) potentiates doxorubicin-induced hypertrophic responses in H9c2 cardiomyocytes by modulating the expression of hypertrophy-associated genes. QT-PCR analysis of MLC-2v, α-MHC and ANP transcripts in cells treated with 1 μM doxorubicin (Dox) for 2 hours followed by a 24 hour treatment in fresh media in the presence and absence of 1 μM TSA. Fold change of mRNA expression shown relative to untreated control H9c2 cells; mean ± standard deviations of triplicates from a representative experiment (total of three independent experiments) are indicated.