Chemical genetic screen identifies lithocholic acid as an anti-aging
                        compound that extends yeast chronological life span in a TOR-independent
                        manner, by modulating housekeeping longevity assurance processes

Alexander A. Goldberg; Vincent R. Richard; Pavlo Kyryakov; Simon D. Bourque; Adam Beach; Michelle T. Burstein; Anastasia Glebov; Olivia Koupaki; Tatiana Boukh-Viner; Christopher Gregg; Mylène Juneau; Ann M. English; David Y. Thomas; Vladimir I. Titorenko

doi:doi:10.18632/aging.100168

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Research Paper Volume 2, Issue 7 pp 393—414

Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes

Figure 10. Outline of pro- and anti-aging processes that are controlled by the TOR and/or cAMP/PKA signaling pathways and are modulated by LCA or rapamycin (RAP) in chronologically aging yeast. The currently accepted (A) and updated, based on this study (B), outlines of pro- and anti-aging processes are shown. Activation arrows and inhibition bars denote pro-aging processes (displayed in green color), anti-aging processes (displayed in red color) or processes whose role in longevity regulation was unknown (displayed in black color). Doted lines denote hypothetical, until this study, processes. See text for details.