Figure 2.FoxO binding sites in the Sestrin locus vary among the species. Genomic
organization and location of FoxO response elements (FRE, GTAAACAA [57]) in the Sesn1
locus of human and mouse [58] and the dSesn
locus of various Drosophila species [59,60] with indicated
genomic span. Gray boxes indicate untranslated exons (UTR), and black boxes
indicate coding exons (CDS). For Drosophila species other than D.
melanogaster, untranslated regions of dSesn mRNAs are currently
unknown. Forward FREs are indicated by red arrows and reverse FREs by blue
arrows.
