Research Perspective Volume 2, Issue 6 pp 369—374

Figure 2. FoxO binding sites in the Sestrin locus vary among the species. Genomic organization and location of FoxO response elements (FRE, GTAAACAA [57]) in the Sesn1 locus of human and mouse [58] and the dSesn locus of various Drosophila species [59,60] with indicated genomic span. Gray boxes indicate untranslated exons (UTR), and black boxes indicate coding exons (CDS). For Drosophila species other than D. melanogaster, untranslated regions of dSesn mRNAs are currently unknown. Forward FREs are indicated by red arrows and reverse FREs by blue arrows.