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Online ISSN: 1945-4589
Hypothesis
|
Volume 2, Issue 5
|
pp. 265–273
Why men age faster but reproduce longer than women: mTOR and evolutionary perspectives
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Figure 2
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Figure 2.
Negative feedback and insulin resistance.
TOR is activated by nutrients and insulin and in turn causes depletion of IRS1/2 and insulin resistance. Whereas nutrients activate TOR, low nutrients and metformin deactivate TOR.
