Research Paper Volume 2, Issue 5 pp 298—310

Figure 1. Comparison of genes upregulated and downregulated in yw/w ¹¹¹⁸ DR, Canton-S CR and dSir2 overexpressed long-lived flies at Day 10. (A) Venn diagram comparing the upregulated and downregulated genes for DR flies in a yw/w¹¹¹⁸ and a Canton-S background at age 10 days. (B) Venn diagram comparing upregulated and downregulated genes in DR long-lived flies and dSir2 overexpressing long-lived flies at age 10 Days. DR flies and dSir2 overexpressing flies are in an identical genetic background. The majority of genes expressed in dSir2 overexpression are also expressed in DR (72% upregulated and 61% downregulated). Verification of microarray data using qPCR is in Supplementary Figure 3.