Figure 1. Open field analysis of exploratory activity and habituation of wild type and Bmal1-/- mice. Locomotor and rearing activity were measured in 5 min increments during 1 hr. (Upper panel) locomotor and rearing activity of wt and Bmal1-/- mice on day1; (middle panel) relative locomotor activity (normalized to average distance covered on day1) and relative rearing activity (normalized to average rearing level on day1) of wt mice on days 1 and 2; (lower panel) relative locomotor and rearing activity of Bmal1-/- mice on days 1 and 2 (* P<0.05).