Figure 1.The PKA
pathway.
The
PKA pathway is a nutrient sensing pathway. In mammals, nutrients are
sensed by a G-protein (GEF) that activates an adenylyl cylase (AC). AC
produces cAMP, which binds to the regulatory subunits (R) of the PKA
holoenzyme, releasing the catalytic subunits (C), which are then free to
enter the nucleus of the cell and activate gene transcription or to
interact with other signaling proteins in the cell.
