Figure 6.Somatic preservation through modulation of AIR-2 and PLK-1 signaling networks in nth-1;xpa-1.Genes encoding
proteins known to stimulate AIR-2 and PLK-1 signaling are downregulated in
nth-1;xpa-1: Plk-1 is known to stimulate
activation of CDK-1, several cyclin B proteins and a G2/M specific cyclin A
through CDC-25.1. Furthermore, PLK-1 and AIR-2 signaling coordinates cytokinesis
and mitotic signaling at kinetochores via in the inner centromere ICP-1,
regulates mitosis and cytokinesis through CYK-4 and ZEN-4, and could
prevent firing of dormant replication origins via downregulation of
MCM2-7. An inhibitor of AIR-2 activation, GSP-2, is one
of the few upregulated genes.
