Figure 2.Effects of continuous administration of NAC on development of eye pathology and muscle strength.(A) Frequency of cataracts
in 30-week old and 45-week old Bmal1-/- mice raised on regular
(closed bars) or NAC-supplemented (open bars) water. Each eye was counted independently; the percentage of
cataracts was determined by dividing the number of cataracts by the total
number of eyes, if an animal was dead at the time of observation, then the
previous score for this animal was used. (B) Age-dependent
changes in muscular strength of WT (green bars) and Bmal1-/- mice
receiving regular (black bars) or NAC-supplemented (red bars) water.
Muscular strength was evaluated as the ability of animals of indicated age
to maintain their weight on the inverted grid. Each
animal was tested five times, if the animal did not fall down for 30 sec
the trial was counted as successful. The percentage of successful trials
was calculated and plotted. No difference was detected between NAC-treated
and control Bmal1-/- animals.
