Research Paper Volume 2, Issue 1 pp 28—42
Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration
Figure 9. Effect of BMP-4 treatment on gene expression of VEGF-A and PEDF in polarized RPE. Expression of VEGF-A (A) and PEDF (B) mRNA in polarized fetal RPE cells vs controls was analyzed by real-time PCR. BMP-4 treatment caused an increase in VEGF-A gene expression, especially at 50, 75, and 100ng/ml BMP-4 treatment which was significantly different from controls (p<0.05). PEDF mRNA did not change with BMP-4 dose for the BMP-4 dose range studied.