Figure 9.Effect of BMP-4 treatment on gene expression of VEGF-A and PEDF in polarized RPE.Expression
of VEGF-A (A) and PEDF (B) mRNA in polarized fetal RPE cells
vs controls was analyzed by real-time PCR. BMP-4 treatment caused an
increase in VEGF-A gene expression, especially at 50, 75, and 100ng/ml
BMP-4 treatment which was significantly different from controls
(p<0.05). PEDF mRNA did not change with BMP-4 dose for the BMP-4 dose
range studied.
