Research Paper Volume 2, Issue 1 pp 28—42
Attainment of polarity promotes growth factor secretion by retinal pigment epithelial cells: Relevance to age-related macular degeneration
Figure 2. Differences in PEDF and VEGF secretion between nonpolarized and polarized RPE from various donors after 24h. Secretion from the polarized RPE cells represent the sum of experimentally determined apical and basolateral secretion values, normalized for total cellular protein. The total secretion increased 34 fold for PEDF and 5.7 fold for VEGF-A (A). Analysis of cellular protein (B) and mRNA (C) showed that expression in polarized human RPE was higher compared to nonpolarized RPE cells.