Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
Figure 5.mIGF-1 prevents Ang II- and IGF-1-induced cell hypertrophy (MF-20 staining) in mouse neonatal primary cardiomyocytes. (A) Neonatal primary cardiomyocytes from wild type or mIGF-1 Tg mice were treated as in Legend of Figure 2B. (B) Cell size and hypertrophy were quantified according to MF-20 staining in the different experimental conditions as in as in Legend of Figure 2B. Results are means ± SE of 3 independent experiments (*,**p versus unstimulated control cells). Bar: 25 μM.