Research Paper Volume 2, Issue 1 pp 43—62
Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity
Figure 11. Simplified scheme illustrating the role of mIGF-1-induced SirT1 activity in protection against Ang II- and PQ-mediated oxidative stress and hypertrophy in cardiomyocytes. Question point and dashed line indicate unanswered issues and hypothetical signaling cross-talk, respectively.