Figure 3.Subsarcolemmal (SS) and intermyofibrillar (IMF) mitochondrial protein import machinery components are increased in young, but not old animals in response to chronic contractile activity. (A).Representative
Western blots of mtHSP70, Tim17, and Tim23 proteins in SS and IMF (B) mitochondrial
subfractions isolated from the control (C) and chronically stimulated (S) limbs
of young and old animals. (C) Graphical summary of the data in
panels A and B expressed as the fold difference of the stimulated, over the
control legs (n = 7-9). (D) Pooled results of the protein
expression data in young, compared to old animals shown above in panel C,
and panel B of Figure 3 (n = 74-86). Data represent the mean ± SEM.
* P < 0.05, stimulated vs. control, † P < 0.05
vs. Young.
Figure 3 — Molecular basis for an attenuated mitochondrial adaptive plasticity in aged skeletal muscle | Aging
