Figure 2.SIRT1 regulates fatty acid oxidation and gluconeogenesis in the liver. Resveratrol, NAD+,
fasting and calorie restriction activate SIRT1, causing deacetylation of
PGC-1α, FOXO1, and
TORC2 which in turn leads to increased fatty acid oxidation and
gluconeogenesis. The exact mechanism underlying how SIRT1 activates PPARα and the precise role of PGC-1α in the SIRT1-mediated glucose
homeostasis remain to be clarified.
