The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

Gino Heeren; Mark Rinnerthaler; Peter Laun; Phyllis von Seyerl; Sonja Kössler; Harald Klinger; Stefanie Jarolim; Birgit Simon-Nobbe; Matthias Hager; Christoph Schüller; Didac Carmona-Gutierrez; Lore Breitenbach-Koller; Christoph Mück; Pidder Jansen-Dürr; Alfredo Criollo; Guido Kroemer; Frank Madeo; Michael Breitenbach

doi:doi:10.18632/aging.100065

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Research Paper Volume 1, Issue 7 pp 622—636

The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

Figure 8B. Old and young cells of the same strains as in A were isolated by elutriation centrifugation and ERCs were analyzed by gel electrophoresis and Southern blotting with an rDNA-specific probe as described in [19]. Thick arrow: chromosomal rDNA repeats; Thin arrow: ERCs (minicircles). Taken together, the results presented in this figure indicate that longevity in the afo1Δ strain is not influenced by the fob1-deletion or the presence of ERCs.