The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

Gino Heeren; Mark Rinnerthaler; Peter Laun; Phyllis von Seyerl; Sonja Kössler; Harald Klinger; Stefanie Jarolim; Birgit Simon-Nobbe; Matthias Hager; Christoph Schüller; Didac Carmona-Gutierrez; Lore Breitenbach-Koller; Christoph Mück; Pidder Jansen-Dürr; Alfredo Criollo; Guido Kroemer; Frank Madeo; Michael Breitenbach

doi:doi:10.18632/aging.100065

← Back

Research Paper Volume 1, Issue 7 pp 622—636

The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

Figure 2A. Segregation of the mutant phenotypes of afo1Δ in meiotic tetrads after outcrossing and influence of the genes adjacent to AFO1. 10μl aliquots of the cultured strains were spotted on SC-glucose and on SC-glucose + oxidants, as indicated in the figure. Cultures were grown to OD₆₀₀ = 3.0 and diluted as indicated. Three out of ten tetrads tested are shown together with two wild type and two afo1 deletion strains.