Figure 1.PARP1 at the crossroad of metabolic stress and inflammation in aging. PARP1 is
activated by cellular stress, e.g. by oxidative damage due to increased
levels of reactive oxygen species (ROS). As NAD+-dependent
enzyme, PARP1 senses energy levels and crosstalks with other NAD+-consuming
enzymes. Over-activation of PARP1 leads to energy depletion and cell death.
On the other hand, PARP1 functions as cofactor for NF-κB-dependent transcription and is
therefore implicated in many inflammatory processes. Both, PARP1-mediated
metabolic stress and PARP1-regulated inflammation can lead to tissue
degeneration underlying many age-related pathologies. See text for further
details.
