Review Volume 1, Issue 5 pp 451—457
Counteracting muscle wasting in aging and neuromuscular diseases: the critical role of IGF-1
Figure 1. Schematic representation of rodent IGF-1 gene. The rodent IGF-1 gene contains six exons (colored boxes), separated by five introns (black lines). Both exons 1 and 2 contain multiple transcription start sites (horizontal arrows). Translation initiation codons (AUG) are located at exons 1, 2 and 3 (vertical arrows). Exons 1, 2 and 3 code for the signal peptide of precursor IGF-1 (red boxes). Exons 5 and 6 each encode distinct portions of the E-peptides (green boxes).