Research Paper Volume 1, Issue 4 pp 382—388
Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease
Figure 1. In an 87 year old AD case, hippocampal tissue sections demonstrate significant localization of pMcm2 protein in NFT, dystrophic neurites, and neuropil threads (B). In another AD case, in the CA3 region, in addition to pathological structures, a few pyramidal neuron nuclei (arrows) have significant pMcm2 accumulation (D). Most control cases, representative case age 61 years, demonstrate no neuronal staining for pMcm2 protein (A), while a few older control cases demonstrate significant nuclear immunolocalization in the pyramidal neurons (control case age 74 years, C) Scale bar= 50 μm.