Figure 1. In an 87 year old AD case, hippocampal tissue sections demonstrate significant
localization of pMcm2 protein in NFT, dystrophic neurites, and neuropil
threads (B). In another AD case, in the CA3 region, in addition to
pathological structures, a few pyramidal neuron nuclei (arrows) have significant
pMcm2 accumulation (D). Most control cases, representative case age
61 years, demonstrate no neuronal staining for pMcm2 protein (A),
while a few older control cases demonstrate significant nuclear
immunolocalization in the pyramidal neurons (control case age 74 years, C)
Scale bar= 50 μm.
