Figure 6.In vivo treatment with NAC reduces oxidative stress within pancreatic β cells.
(A) Atg7F/+:Rip2-Cre
or Atg7F/F:Rip2-Cre mice that were untreated or treated with the
antioxidant NAC for 12 weeks. At 16 weeks of age, mice were sacrificed and
serial sections of pancreatic tissue were analyzed for p62 and insulin or (B)
nitrotyrosine and insulin. (C) Quantification of nitrotyrosine
staining in islets of control mice, Atg7-deficient animals or
Atg7-deficient mice treated for 12 weeks with NAC (n=3 animals per group).
Graph represents the mean+/- SEM. **; p≤0.01.
