Research Paper Volume 1, Issue 4 pp 425—437
Mitochondrial dysfunction and oxidative stress mediate the physiological impairment induced by the disruption of autophagy
Figure 6. In vivo treatment with NAC reduces oxidative stress within pancreatic β cells. (A) Atg7F/+:Rip2-Cre or Atg7F/F:Rip2-Cre mice that were untreated or treated with the antioxidant NAC for 12 weeks. At 16 weeks of age, mice were sacrificed and serial sections of pancreatic tissue were analyzed for p62 and insulin or (B) nitrotyrosine and insulin. (C) Quantification of nitrotyrosine staining in islets of control mice, Atg7-deficient animals or Atg7-deficient mice treated for 12 weeks with NAC (n=3 animals per group). Graph represents the mean+/- SEM. **; p≤0.01.