Review Volume 1, Issue 4 pp 372—381
Aging of the inceptive cellular population: the relationship between stem cells and aging
Figure 2. Pathways associated with aging in ASCs. Bmi-1, Cbx7 (PRC1), Hmga2 are proteins that have been shown to increase in expression levels in aging ASCs along with corresponding inhibition of the INK4a/ARF locus leading to a progression into senescence and apoptosis. Rb2/p130 also shows an increase in senescent MSCs, this could be a result of HDAC1 - Rb2/p130 complex repressing E2F target gene transcription and initiating the senescence pathway.