Figure 2.Pathways associated with aging in ASCs. Bmi-1, Cbx7
(PRC1), Hmga2 are proteins that have been shown to increase in expression
levels in aging ASCs along with corresponding inhibition of the INK4a/ARF
locus leading to a progression into senescence and apoptosis. Rb2/p130
also shows an increase in senescent MSCs, this could be a result of HDAC1 -
Rb2/p130 complex repressing E2F target gene transcription and initiating
the senescence pathway.
