Research Paper Volume 1, Issue 2 pp 234—244

Figure 1. Increased microglial activation in the hippocampus 7 d after Aβ _1-42 administration. Representative photomicrographs of the CA1 and CA3 of the hippocampus from WT mice (A, D) injected with Aβ_1-42 that shows numerous activated microglia with short, less-ramified processes, perikaryal hypertrophy, and amoeboid appearance (G). CA1 and CA3 areas of the hippocampus from Aβ_1-42-injected COX-1^-/- mice (B, E) show many resting microglia with ramified morphology (H). Scale bar: A-F, 100 μm; G-I, 50 μm. (J) Comparison of the number of activated microglia from the CA3 area. Mean ± SEM (n = 3-4 per group); ^**P < 0.01 compared with the Aβ_42-1-injected WT mice; ^##P < 0.01 compared with the Aβ_1-42-injected WT mice.