Research Paper Volume 1, Issue 2 pp 191—211
A screen of apoptosis and senescence regulatory genes for life span effects when over-expressed in Drosophila
Figure 3. Effect of transgene over-expression on survival of adult flies. Apoptosis and senescence-related genes wingless, Ras85D, and Ras85D activated form were over-expressed during larval development or in adults, and assayed for effects on adult life span in male and female flies, as indicated. The life span assays were performed at 29°C. Open circles represent the no-drug control ("-"). Solid squares represent adults treated with drug ("A"). Grey triangles represent larvae on drug ("L"). Survival curves are plotted as a function of adult age in days. Median life span of each cohort is presented along with p value for log rank test (in parentheses). (A, C, E, G) male flies. (B, D, F, H) female flies. (A, B) Control flies containing the driver and no target transgene. (C, D) Ras85D activated form. (E, F) Ras85D wild-type. (G, H) wingless.