Advance | Aging

Stopping the aged brain from eating itself

Mar Puigdellívol, Guy C. Brown,

https://doi.org/10.18632/aging.205887

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Germicidal lamps using UV-C radiation may pose health safety issues: a biomolecular analysis of their effects on apoptosis and senescence

Nicola Alessio, Alessia Ambrosino, Andrea Boggi, Domenico Aprile, Iole Pinto, Giovanni Galano, Umberto Galderisi, Giovanni Di Bernardo,

https://doi.org/10.18632/aging.205787

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Cell type-dependent modulation of senescence features using Weo electrolyzed water

Brenda L. Court-Vazquez, Shirley A. Arroyo-Vizcarrondo, Jonathan A. Poli, Lara Nyman, Kelly Halderman, Anthony Ginter, Pierre-Yves Desprez,

https://doi.org/10.18632/aging.205789

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Caloric restriction mitigates age-associated senescence characteristics in subcutaneous adipose tissue-derived stem cells

Somaiah Chinnapaka, Hamid Malekzadeh, Zayaan Tirmizi, Asim Ejaz,

https://doi.org/10.18632/aging.205812

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Establishment and verification of a prognostic model based on coagulation and fibrinolysis-related genes in hepatocellular carcinoma

Meng Fan, Le Lu, Hao Shang, Yuxuan Lu, Yi Yang, Xiuyan Wang, Hongwei Lu,

https://doi.org/10.18632/aging.205699

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CCNA2 and KIF23 are molecular targets for the prognosis of adenoid cystic carcinoma

Yongbin Di, Haolei Zhang, Bohao Zhang, Tianke Li, Dan Li,

https://doi.org/10.18632/aging.205703

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Construction of exosome-related genes risk model in kidney cell carcinoma predicts prognosis and immune therapy response

Chao Gao, Wei Huang, Qiang Su, Jingxian Li, Wei Wang, Yuanjiong Qi, E Du, Zhihong Zhang,

https://doi.org/10.18632/aging.205767

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GJB3: a comprehensive biomarker in pan-cancer prognosis and immunotherapy prediction

Jingtong Zeng, Xianjie Li, Yifan Zhang, Bo Zhang, Hanqing Wang, Shihao Bao, Lingling Zu, Hao Zhang, Yuan Cheng, Quanying Tang, Xiaohong Xu, Song Xu, Zuoqing Song,

https://doi.org/10.18632/aging.205774

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Causal association of metformin treatment with diverse cardiovascular diseases: a Mendelian randomization analysis

Kaiyuan Li, Peng Liu, Jun Ye, Miao Liu, Li Zhu,

https://doi.org/10.18632/aging.205775

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Iron retardation in lysosome protects senescent cells from ferroptosis

Yujing Feng, Huaiqing Wei, Meng Lyu, Zhiyuan Yu, Jia Chen, Xinxing Lyu, Fengfeng Zhuang,

https://doi.org/10.18632/aging.205777

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Immune cell senescence and exhaustion promote the occurrence of liver metastasis in colorectal cancer by regulating epithelial-mesenchymal transformation

Sen Lin, Lanyue Ma, Jiaxin Mo, Ruiqi Zhao, Jinghao Li, Mengjiao Yu, Mei Jiang, Lisheng Peng,

https://doi.org/10.18632/aging.205778

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A real-world study was conducted to develop a nomogram that predicts the occurrence of anastomotic leakage in patients with esophageal cancer following esophagectomy

Chenglin Li, Wei Song, Jialing Zhang, Zhongneng Xu, Yonggang Luo,

https://doi.org/10.18632/aging.205780

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Long non-coding RNA HOTAIR: from pan-cancer analysis to colorectal cancer-related uridine metabolism

Xuyu Chen, Siying Wang, Xin Jiang, Min Zhang, Yanbing Ding,

https://doi.org/10.18632/aging.205781

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The identification of a N⁶-methyladenosin-modifed immune pattern to predict immunotherapy response and survival in urothelial carcinoma

Xudong Mao, Xianjiong Chen, Zhehao Xu, Lifeng Ding, Wenqin Luo, Yudong Lin, Ruyue Wang, Liqun Xia, Mingchao Wang, Gonghui Li,

https://doi.org/10.18632/aging.205782

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Identifying lncRNAs and mRNAs related to survival of NSCLC based on bioinformatic analysis and machine learning

Wei Yue, Jing Wang, Bo Lin, Yongping Fu,

https://doi.org/10.18632/aging.205783

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Unraveling the unfolded protein response signature: implications for tumor immune microenvironment heterogeneity and clinical prognosis in stomach cancer

Wenhao Ouyang, Yajing Liu, Hong Huang, Yujing Tan, Zhenjun Huang, Xueyuan Jia, Yunfang Yu, Herui Yao,

https://doi.org/10.18632/aging.205784

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Left ventricular systolic dysfunction predicts clinical prognosis in patients with acute ischemic stroke after intravenous thrombolysis

Chi Zhang, Jun-Cang Wu, Zheng Tan, Xiao-Lu He, Fei Li, Long Wang, Yu Wang,

https://doi.org/10.18632/aging.205786

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Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials

Chih-Ying Lee, Lung Chan, Chaur-Jong Hu, Chien-Tai Hong, Jia-Hung Chen,

https://doi.org/10.18632/aging.205788

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Leptin attenuates the osteogenic induction potential of BMP9 by increasing β-catenin malonylation modification via Sirt5 down-regulation

Kai-Xin Ke, Xiang Gao, Lu Liu, Wen-Ge He, Yue Jiang, Cheng-Bin Long, Gan Zhong, Zheng-Hao Xu, Zhong-Liang Deng, Bai-Cheng He, Ning Hu,

https://doi.org/10.18632/aging.205790

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Predictive value of FCGBP expression for treatment response and survival in rectal cancer patients undergoing chemoradiotherapy

Yu-Ting Su, Chung-Hsing Chen, Jui-Wen Kang, Hsin-Yu Kuo, Ching-Chieh Yang, Yu-Feng Tian, Cheng-Fa Yeh, Chia-Lin Chou, Shang-Hung Chen,

https://doi.org/10.18632/aging.205791

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Improvement of skin wound healing by giant salamander skin mucus gel wrapped with bone marrow mesenchymal stem cells via affecting integrin family molecules

Wei Li, Dayong Du, Yan Huang, Cui Xu, Yang Liu, Xiaohong Wu, Jie Yang, Zhipeng Liu, Jianxin Ma, Chaoji Huangfu,

https://doi.org/10.18632/aging.205792

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IL21 inhibits miR-361-5p to promote MAP3K9 and further aggravate the progression of shoulder arthritis

Kangning Hao, Pengchao Lin, Jing Li, Jie Hu, Jiangyong Wang, Fei Li,

https://doi.org/10.18632/aging.205793

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Human umbilical cord mesenchymal stem cells promote steroid-induced osteonecrosis of the femoral head repair by improving microvascular endothelial cell function

Junwen Chen, Wenyi Jin, Changheng Zhong, Wenxiang Cai, Liangkun Huang, Jianlin Zhou, Hao Peng,

https://doi.org/10.18632/aging.205794

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Trigeminal nerve electrical stimulation attenuates early traumatic brain injury through the TLR4/NF-κB/NLRP3 signaling pathway mediated by orexin-A/OX1R system

Junwei Kang, Yifan Zhou, Qi Xiong, Xiaoyang Dong,

https://doi.org/10.18632/aging.205795

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Effects of butyrate on intestinal ischemia-reperfusion injury via the HMGB1-TLR4-MyD88 signaling pathway

Yuanyuan Rong, Meili Xu, Tao Hu, Shasha Zhang, Jianfeng Fu, Huaqin Liu,

https://doi.org/10.18632/aging.205797

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A systematic pan-cancer analysis identifies LDHA as a novel predictor for immunological, prognostic, and immunotherapy resistance

Qiqi Zhang, Yuanning Luo, Bingshuo Qian, Xiuhua Cao, Caijun Xu, Kan Guo, Runlan Wan, Yaling Jiang, Tiecheng Wang, Zhiqiang Mei, Jinbiao Liu, Chaoxiang Lv,

https://doi.org/10.18632/aging.205800

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AURKB promotes colorectal cancer progression by triggering the phosphorylation of histone H3 at serine 10 to activate CCNE1 expression

Ling Li, Ke Xie, Honghu Xie, Lei Wang, Zhong Li, Qicheng Lu, Jin Feng,

https://doi.org/10.18632/aging.205801

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The prognostic value and immunological role of MVP in pan-cancer study

Chunlin Li, Min Gao, Nashunbayaer Zha, Gang Guo,

https://doi.org/10.18632/aging.205802

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Sphingolipids in prostate cancer prognosis: integrating single-cell and bulk sequencing

Shan Zhou, Li Sun, Fei Mao, Jing Chen,

https://doi.org/10.18632/aging.205803

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Bioinformatics analysis for constructing a cellular senescence-related age-related macular degeneration diagnostic model and identifying relevant disease subtypes to guide treatment

Shan Luo, Qiang Hu, Bo Jiang, Zhongyu Zhang, Dawei Sun,

https://doi.org/10.18632/aging.205804

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KLF4 inhibited the senescence-associated secretory phenotype in ox-LDL-treated endothelial cells via PDGFRA/NAMPT/mitochondrial ROS

Haoran Ding, Jing Tong, Hao Lin, Fan Ping, Tongqing Yao, Zi Ye, Jiapeng Chu, Deqiang Yuan, Kangwei Wang, Xuebo Liu, Fei Chen,

https://doi.org/10.18632/aging.205805

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Constructing a novel prognostic model for triple-negative breast cancer based on genes associated with vasculogenic mimicry

Yu Ren, Luyi Feng, Zhihua Tan, Fulin Zhou, Shu Liu,

https://doi.org/10.18632/aging.205806

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Revealing prognostic insights of programmed cell death (PCD)-associated genes in advanced non-small cell lung cancer

Weiwei Dong, He Zhang, Li Han, Huixia Zhao, Yue Zhang, Siyao Liu, Jiali Zhang, Beifang Niu, Wenhua Xiao,

https://doi.org/10.18632/aging.205807

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4-hydroxysesamin protects rat with right ventricular failure due to pulmonary hypertension by inhibiting JNK/p38 MAPK signaling

Lingnan Zhang, Xinshun Gu,

https://doi.org/10.18632/aging.205808

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Pan-cancer analysis of LRRC59 with a focus on prognostic and immunological roles in hepatocellular carcinoma

Boyu Pan, Jun Cheng, Wei Tan, Xin Wu, Qizhi Fan, Lei Fan, Minghui Jiang, Rong Yu, Xiaoyun Cheng, Youwen Deng,

https://doi.org/10.18632/aging.205810

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RNA sequencing-based approaches to identifying disulfidptosis-related diagnostic clusters and immune landscapes in osteoporosis

Peng Zhang, Bing Li, Honglin Chen, Zhilin Ge, Qi Shang, De Liang, Xiang Yu, Hui Ren, Xiaobing Jiang, Jianchao Cui,

https://doi.org/10.18632/aging.205813

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Single-cell BCR and transcriptome analysis reveals peripheral immune signatures in patients with thyroid-associated ophthalmopathy

Qian Li, Ningyu An, Cheng Liu, Yungang Ding, Cuixia Yang, Xiumei Ma, Wei Yang, Junfeng Piao, Jinyan Zhu, Junxiu Liu,

https://doi.org/10.18632/aging.205814

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Construction and validation of nomogram model for predicting the risk of ventricular arrhythmia after emergency PCI in patients with acute myocardial infarction

Wei Wang, Min Chen, Jiongchao Guo, Yuqi Wang, Jing Zhang,

https://doi.org/10.18632/aging.205815

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HLA-B and TIMP1 as hub genes of the ventricular remodeling caused by hypertension

Gai-Feng Hu, Ling-Bing Meng, Jianyi Li, Jiapei Xu, Hong-Xuan Xu, De-Ping Liu,

https://doi.org/10.18632/aging.205816

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Cancer-associated fibroblast-derived gene signature discriminates distinct prognoses by integrated single-cell and bulk RNA-seq analyses in breast cancer

Zhou Fang, Yi-Ling Han, Zhi-Jie Gao, Feng Yao,

https://doi.org/10.18632/aging.205817

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Deciphering the causal relationship between plasma and cerebrospinal fluid metabolites and glioblastoma multiforme: a Mendelian Randomization study

Zhiwei Zhou, Haibin Leng,

https://doi.org/10.18632/aging.205818

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Intracranial aneurysm circulating exosome-derived LncRNA ATP1A1-AS1 promotes smooth muscle cells phenotype switching and apoptosis

Chao Wang, Hong Li, Han Zhou, Yifan Xu, Shifang Li, Meng Zhu, Bing Yu, Yugong Feng,

https://doi.org/10.18632/aging.205821

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A cuproptosis-based prognostic model for predicting survival in low-grade glioma

Zongren Zhao, Yuanhao Ma, Yu Liu, Zhongjun Chen, Jinyu Zheng,

https://doi.org/10.18632/aging.205834

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Comprehensive bioinformatics analytics and in vivo validation reveal SLC31A1 as an emerging diagnostic biomarker for acute myocardial infarction

Shujing Zhou, Longbin Wang, Xufeng Huang, Ting Wang, Yidan Tang, Ying Liu, Ming Xu,

https://doi.org/10.18632/aging.205199

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ANGPTL4, a direct target of hsa-miR-133a-3p, accelerates lung adenocarcinoma lipid metabolism, proliferation and invasion

Qihao Hu, Shi Chen, Yukun Li, Teng Hu, Jianpeng Hu, Cheng Wang, Fei Yang, Xiang Yang, Feng Zhou, Zhengdong Liu, Wei Xu, Ji Zhang,

https://doi.org/10.18632/aging.205313

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Teneligliptin alleviates diabetes-related cognitive impairment by inhibiting the endoplasmic reticulum (ER) stress and NLRP3 inflammasome in mice

Weifeng Wang, Juanjuan Zhang,

https://doi.org/10.18632/aging.205333

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Local anesthetic levobupivacaine induces ferroptosis and inhibits progression by up-regulating p53 in non-small cell lung cancer

Minghua Meng, Meiling Huang, Cuicui Liu, Jiming Wang, Weihua Ren, Shaomin Cui, Jianhua Gu, Jinlan Xie, Bin Ma, Guangzhu Yang, Shuncheng He,

https://doi.org/10.18632/aging.203138

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Identification of an immune subtype predicting survival risk and immune activity in hepatocellular carcinoma

Feng Zhao, Nuo Xu, Jiali Yang, Bo Li, Jianwei Shi, Yuanyuan Zheng, Longjin Xu,

https://doi.org/10.18632/aging.202953

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The beginning of becoming a human

Polina A. Loseva, Vadim N. Gladyshev,

https://doi.org/10.18632/aging.205824

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