Research Paper Advance Articles

DNA methylation entropy is a biomarker for aging

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Figure 3. Model performance across three methylation metrics and two regression methods. Pearson’s correlation coefficient, equation of best-fit line, and MAE between predicted and chronological age are included. (AD) Predicted versus chronological age using average methylation, CHALM, entropy, and a combination of these metrics with elastic net regression. (EH) Predicted versus chronological age with neural network regression.