Research Perspective Advance Articles

Figure 1. RGS14 KO model of longevity. (A) Kaplan-Meier survival curves for RGS14 KO and WT mice showed significantly augmented survival in RGS14 KO mice. (B) Maximum lifespan was significantly greater in RGS14 KO mice than in WT mice for both males and females. In addition, medium and maximum lifespan were greater in female RGS14 KO mice than in male RGS14 KO mice. (C) Furthermore, 24 month old RGS14 KO mice did not show the aging phenotype normally present in WT mice of similar age, including body atrophy, loss of hair and greying of fur color. In support of the key role of BAT in aging, old WT RGS14 KO BAT recipient mice, which had BAT transplanted at 3–4 months of age, had the appearance of healthful aging similar to the old RGS14 KO mice. A representative example of each is shown in panel C. For median lifespan analysis, a Mood’s Median Test, was used to determine differences in median lifespan. A Student’s t-test was used to test differences in maximum lifespan. ^*p < 0.05 vs. WT, ^#p < 0.05 vs. male. Reprinted from Vatner DE, et al Aging Cell. 2018; 17(4).