Figure 2. Urine levels of uremic toxins in cohort 1. The levels of urinary uremic toxins were normalized by creatinine (A–E). The box and bars represent mean and SEM. TMAO, trimethylamine N-oxide; IxS, indoxyl sulfate; PCS, p-cresol sulfate; PS, phenyl sulfate; IAA, indole-3-acetic acid; Cr, creatinine; CKD2, CKD stage 2. Asterisks (*) denote P-values from the Mann-Whitney test, *P<0.05, **P<0.01.