Research Paper Advance Articles
DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility
Figure 2. Distribution of DNAmAge/AgeAccelDiff/IEAA by selected BC-risk factors. By BMI, (A–C); HEI-2015, (D–F); SMK, (G–I); ALC, (J–L). (ALC, dietary alcohol categorized by moderate drink (14 g); AgeAccelDiff, epigenetic age acceleration as departure of DNAmAge from chronologic age; IEAA, intrinsic epigenetic age acceleration as residuals adjusted for cell composition; BC, breast cancer; BMI, body mass index; Cat, Categories; DNAmAge, DNA methylation–based marker of aging; HEI, healthy eating index; SMK, pack-years of smoking.) (A) BMI, DNAmAge (B) BMI, AgeAccelDiff (C) BMI, IEAA (D) HEI-2015, DNAmAge (E) HEI-2015, AgeAccelDiff (F) HEI-2015, IEAA (G) SMK, DNAmAge (H) SMK, AgeAccelDiff (I) SMK, IEAA (J) ALC, DNAmAge (K) ALC, AgeAccelDiff (L) ALC, IEAA.