Research Paper Volume 16, Issue 21 pp 13237—13251
Thermotherapy has sexually dimorphic responses in APP/PS1 mice
Figure 5. Sexually dimorphic spatial navigation responses to thermotherapy in APP/PS1 mice. Average latency to the platform during the five MWM training sessions (A). A two-way ANOVA with Sidak’s post hoc was used to determine significant time differences due to thermotherapy across training days. The number of platform entries (B), latency to first platform entry (C), number of annulus 40 entries (D), latency to first annulus 40 entry (E), and swimming speed (F) during the delayed MWM probe challenge. A two-tailed t-test was used to determine thermotherapy effects on probe challenge parameters within a sex and genotype. The number of animals is inset on each bar graph. *p < 0.05, **p < 0.01.