Research Paper Volume 16, Issue 21 pp 13237—13251

Figure 4. Hepatic, perigonadal white adipose tissue, and skeletal muscle mRNA expression. Hepatic mRNA expression of insulin receptor (INSR; A), phosphatidylinositol 3-kinase (PI3K; B), AKT1 (C), glucose transporter 2 (GLUT2; D), glucokinase (GCK; E), and glucose 6-phosphatase (G6PC; F) relative to B2M. Perigonadal WAT mRNA expression changes of uncoupling protein 1 (UCP1; G), PGC-1α (PPARGC1A; H), INSR (I), tumor necrosis factor α (TNFA; J), and interleukin 6 (IL6; K) relative to B2M. GLUT4 (L) and 1 (M) mRNA expression relative to GAPDH in skeletal muscle. A two-tailed t-test was used to determine mRNA expression fold changes within a genotype and sex. The number of animals is either inset or above the error bars on each bar graph. ^*p < 0.05, ^**p < 0.01, ^***p < 0.001.