Research Paper Volume 16, Issue 21 pp 13340—13355
Identification of the m6A/m5C/m1A methylation modification genes in Alzheimer’s disease based on bioinformatic analysis
Figure 2. Differential analysis of three regulators of methylation modification in Alzheimer’s disease. (A) Heatmap illustrating the expression data of 24 regulators. (B) Chromosomal localization of 24 regulators. (C, D) Analysis of the correlation between the 24 differentially expressed regulatory factors, with red indicating positive association and green indicating negative association. The correlation coefficient is represented by the pie chart area. (E) Boxplots demonstrating variations in immune infiltration between AD and non-AD controls. *P < 0.05, **P < 0.01, ***P < 0.001. (F) Correlation analysis of 24 methylated differential genes with 22 immune cell types. *P < 0.05, **P < 0.01, ***P < 0.001.