Figure 4. Performance of the DMR signature in the model validation cohort. (A) Heat map of the methylation value of the 15 DMRs in low-risk (n = 27) and high-risk (n = 58) groups. (B) KM curves for DFS in the model validation cohort. (C) Time-dependent ROC curves in the model validation cohort. (D) Comparison of the risk score in the different clinical subgroups including age, sex, smoking history, and TNM stage.