Research Paper Volume 16, Issue 21 pp 13323—13339
A differentially-methylated-region signature predicts the recurrence risk for patients with early stage lung adenocarcinoma
Figure 2. Identification of DMRs in the patients with early stage LUAD. (A) Difference analysis yielded a total of 468 DMRs, including 438 hypermethylated regions and 30 hypomethylated regions in the marker discovery cohort (LUAD: n = 39; normal: n = 39). (B) Principal component analysis between LUAD and normal lung samples based on the methylation value of 468 DMRs. (C) Heatmap of the 468 DMRs in the marker discovery cohort. (D) Annotation information of the 468 DMRs, including location and the function of corresponding genes.